If you begin using Dupixent (dupilumab) and it works well for your condition, there’s no set time at which you would stop the medication.

In most cases, you’ll stay on Dupixent long term, or as long as you’re benefiting and tolerating the drug.

Dupixent is a biologic medication approved for multiple chronic inflammatory conditions, including asthma and atopic dermatitis. Most of the symptoms Dupixent treats persist over time, which is why Dupixent is often used as a long-term maintenance treatment.

How long you stay on Dupixent depends on how you respond to the drug and how your condition evolves.

The 2025 prescribing drug information describes Dupixent (dupilumab) as an ongoing add-on or maintenance therapy. It does not provide a formal recommended treatment length, and there are no other general guidelines on how long you should be on Dupixent.

Since Dupixent is prescribed for chronic (long-standing) conditions, treatment usually continues while symptoms respond to treatment.

Clinical data on Dupixent for conditions like atopic dermatitis and asthma show that many people remain on Dupixent for years while symptoms continue to respond to the drug.

If your symptoms respond well to Dupixent, a doctor may consider tapering other therapies or periodically evaluating whether you still need to take Dupixent or if you can space out your injections.

Studies show that many people with atopic dermatitis stop taking Dupixent or reduce their dose because their symptoms go into remission for a few months.

One 2022 study found that over half of people who discontinued dupilumab maintained remission for an average of about 10 months. However, this small study was not conducted in the U.S., and it used different treatment guidelines, so the results may not apply to everyone taking the medication.

In every case, it’s important to follow your doctor’s instructions and recommendations.

If you discontinue Dupixent completely, there’s a chance your symptoms may flare or intensify. This is particularly the case if you are not taking any other medications for your condition.

For some people, symptoms may not return immediately after stopping Dupixent. A healthcare professional may want to monitor your symptoms to determine if you need to take the drug again or switch to another therapy.

Shorter interruptions, such as missed doses, are accounted for in the dosing instructions, so they should not have a great impact on your symptoms. Longer breaks from Dupixent carry less predictable outcomes.

Still, treatment may be paused or stopped if the condition goes into remission (with no symptoms) or due to life changes (such as pregnancy or nursing, or financial challenges).

What’s important is that you work with a medical professional who can help you monitor your symptoms and determine the best course of action.

Do you need to taper off Dupixent?

The prescribing information doesn’t include a tapering schedule for Dupixent. However, some studies have explored the tapering of dupilumab, the active ingredient in Dupixent.

A large 2023 study (full text available by clicking on PDF) reported successful tapering of dupilumab in most people (83% of 401 individuals) with low disease activity in atopic dermatitis.

The study, conducted in the Netherlands, followed adults with moderate to severe eczema who’d been on dupilumab for more than a year. They were able to stretch their injection cadence from every 2 weeks to every 3 to 4 weeks and still keep their eczema symptoms under control.

The study suggests that tapering by widening the dosing interval may be possible for some people with atopic dermatitis once symptoms are mild.

A 2024 study in 1,286 people also found that dupilumab maintained its effectiveness after 5 years of treatment for atopic dermatitis. Two-thirds of the people (children, adults, and older adults) in this study were able to taper the drug to an injection every 3 to 4 weeks.

A doctor may consider the following when determining if you stop or stay on Dupixent:

  • side effects of Dupixent or related new diagnoses
  • flare frequency and severity (how well symptoms are managed)
  • convenience (cost, access to the drug, coverage)
  • personal preference (how you feel about taking the drug)
  • other therapies you’re following
  • underlying diagnosis (if it needs a maintenance dose)