Dupixent (dupilumab) is a prescription medication used to treat conditions such as eczema, asthma, and chronic sinus issues. This drug is given as an injection under the skin, which you can do yourself at home.

While it might seem a little intimidating at first, the process is designed to be simple. However, it’s good to know what to do if an injection doesn’t go exactly as planned. This article will walk you through the right way to inject Dupixent and what to do if you run into a problem.

close up of hand injecting dupixent into abdomenShare on Pinterest
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Injecting Dupixent properly is the best way to help ensure the drug works well and causes the least amount of pain.

Here’s a simple guide to make your injection as easy as possible:

  1. Prep time: First, take the Dupixent pen or syringe out of the fridge and let it sit at room temperature for at least 30 minutes. Trying to inject it cold can make it sting more.
  2. Choose a spot: The best places to inject are your thigh or your stomach (at least 2 inches away from your belly button). If someone else is helping you, they can use the back of your upper arm. Ensure you rotate your injection site each time so you don’t keep injecting in the same spot.
  3. Clean up: Wash your hands with soap and water. Then, use an alcohol wipe to clean the skin where you’re going to inject. Let it air dry completely.
  4. Ready, set, go: Gently pinch your skin at the injection site. This helps create a firm area and ensures the medication goes into the fatty layer just under your skin, not into your muscle. Injecting into a muscle can be more painful.
  5. Injecting: If you have the prefilled pen, place it firmly against your skin and push the button. You’ll hear a click when the injection starts and a second click when it’s done. Hold it in place until the yellow bar fills the window. If you’re using a syringe, push the plunger down slowly and smoothly. A steady motion causes less discomfort.
  6. After the shot: Once you’re done, lift the pen or syringe straight off your skin. Gently press a cotton ball or a piece of gauze on the spot for a few seconds. Do not rub the area, as this can cause the medication to leak out. Discard any unused product remaining in the prefilled syringe or pen.

If you’re unsure about any part of the injection process, check out the step-by-step videos on the drug manufacturer’s website.

Sometimes, a little bit of Dupixent might leak from the injection site after you pull the needle out. This is fairly common and doesn’t usually mean you didn’t get your full dose.

  • Don’t worry: A small leak is natural and doesn’t affect how well the medication works.
  • Don’t reinject: Don’t try to give yourself another shot. You’ve already received most of the dose.
  • Just press: Simply press a cotton ball or gauze on the spot for a moment.

If you’re concerned about how much leaked, talk with your doctor or pharmacist, but it’s unlikely to be a problem.

While the pens are very reliable, sometimes a rare issue can occur.

  • No clicks or movement: If you press the button and don’t hear clicks or see the yellow bar move, the pen may not be working.
  • Don’t try to fix it: Immediately throw the pen away in a sharps container.
  • Start over: Grab a new, unused pen and follow the injection steps again.
  • Tell your doctor: Let your doctor or pharmacist know what happened. They can help you get a replacement.

Here are some common questions and answers about injecting Dupixent.

What happens if I inject Dupixent when it’s cold?

You’ll likely feel a stinging or burning sensation at the injection site. While it doesn’t affect the drug itself, it can be uncomfortable. That’s why it’s important to let Dupixent warm up to room temperature for at least 30 minutes before injecting it.

What happens if I inject Dupixent in the wrong spot?

If you accidentally inject the drug into a muscle instead of under your skin, it will probably be more painful and might cause more bruising. The medication might not be absorbed as well, which could reduce its effectiveness. If this happens, don’t worry too much — make a note of it and mention it to your doctor at your next appointment.

However, if you feel a lot of pain or have symptoms of a serious reaction, such as hives or difficulty breathing, call 911 or your local emergency number and get medical help immediately.

Learning how to give yourself Dupixent injections takes a little practice. By following the right steps, such as letting the medication warm up, choosing a good injection spot, and gently pinching your skin before inserting the needle, you can help ensure your injection is as effective and pain-free as possible. If the injection doesn’t go quite right, remember that small mistakes are usually okay. The most important part is to follow the instructions and always talk with your doctor or pharmacist if you have any questions or concerns.

Disclaimer: MyistyClan has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.